Endocrine Abstracts

Introduction: Cushing’s syndrome usually presents with a phenotype including central obesity, striae, hypertension and diabetes. We report a case of Cushing’s syndrome presenting in an atypical manner.Case: A 73 year old lady was referred to neurology with a year’s history of progressive limb wasting, weakness and recurrent falls. The neurology team diagnosed accelerated sarcopenia. Investigations included CK (normal), EMG (suggested myopa...

Background: Hyperosmolar hyperglycaemic state (HHS) is a life-threatening condition that can be the initial presentation of type 2 diabetes mellitus. This condition is characterized by severe hyperglycaemia, a high serum osmolality and dehydration without accumulation of ketoacids. We report two patients who presented with mixed features of HHS and DKA.Case 1: An 11-year-old Afro-Caribbean boy with severe developmental delay presented with a 4-week histo...

Background: Low vitamin D levels have been linked to stunted growth, lower bone mineral density and health. Optimal levels of vitamin D are not adequately defined and guidance regarding supplementation is limited.Aim: To identify vitamin D levels in a cohort of Caucasian children aged 0–16 years, and describe how preterm birth, obesity, age and malabsorptive conditions correlate with sub-optimal levels.Methods: We obtained 368...

Background: We report a case of a 35-year-old male presenting with pituitary dysfunction secondary to an optochiasmal cavernoma.The gentleman was initially referred with gynaecomastia and biochemical tests consistent with secondary hypogonadism. On further questioning he also reported extremely lethargy, difficulties with weight loss and poor libido. Examination was consistent with features of hypogonadism with reduced body hair, bilateral gynaecomastia ...

A 56 year old lady was investigated by her GP for arthralgia and found to be thyrotoxic (TSH < 0.01 mU/l, free T4 34.8 (10–20 pmol/l), TPO 50 (<35 IU/ml)). She gave a history of anterior uveitis some 20 years earlier. She was commenced on carbimazole and referred to the endocrinology clinic, where her thyroid function rapidly normalised and a biochemical diagnosis of subacute thyroiditis was made. Thyroid pertechnatate scan showed reduced uptake throughout the gl...

Objective: To prospectively evaluate the results of laparoscopic ileal interposition (II) with diverted sleeve gastrectomy (DSG) for control of type 2 diabetes mellitus (T2DM) and related metabolic abnormalities.Methods: All patients underwent II +DSG. They had T2DM ≥5 years with poor glycemic control despite adequate dosage of oral hypoglycemic agents (OHAs) and/ or insulin. The primary outcome was remission of diabetes (HbA1c <6.5% without OH...

Augmented pervasiveness of type 2 diabetes mellitus and obesity has amplified the medical necessitate for new agents to treat these disease states. Both type 2 diabetes and obesity are connected to the resistance to the hormones insulin and leptin. Protein tyrosine phosphatase 1B (PTP1B) has been shown to function as negative regulator of insulin signalling as well as leptin signal transduction. At present there are copious compounds synthesized as PTP1B inhibitors. The develo...

Background: Alzheimer’s disease (AD) is the most common form of dementia in the elderly. AD is characterized by the presence of amyloid plaques which are formed from deposits of b-amyloid protein (Ab). These changes increase during menopausal condition in females when the level of estradiol is decreased.Objective: The objective of this study was to investigate neuroprotective potential of 17β estradiol (E2) treatment on the activities of acetyl...

Introduction: Vitamin D deficiency is increasingly being recognized as a metabolic disorder in temperate climates with various bone, cardiovascular and systemic manifestations. However topical, it is important to exclude tumour induced osteogenic osteomalacia as a possible aetiology in severe vitamin D deficiency when other risk factors (vegetarian diet, ethnicity, etc.) are absent. Early diagnosis of malignant tumors could be life saving and their resection may make this vita...

Introduction: Vitamin D deficiency is increasingly being recognized as a widely prevalent metabolic disorder in temperate climates with various systemic manifestations. However topical, it is important to exclude tumour induced osteogenic osteomalacia as a possible aetiology in severe vitamin D deficiency when other risk factors (vegetarian diet, ethnicity, etc.) are absent. Early diagnosis of malignant tumours could be life saving and their resection may make this vitamin D r...